但这种垄断格局,即将被打破,多款在研新药正从作用机制到给药方式,向Vosoritide发起挑战。Ascendis的TransCon-CNP通过包裹技术延长了药物作用时间,实现了周剂给药,目前正处于FDA审批阶段;而BridgeBio的口服药Infigratinib,则从作用机制到用药体验实现全面突破。
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All of the examples demonstrating ordered dithering so far have been produced using a specific type of threshold matrix commonly known as a Bayer matrix. In theory however any matrix could be used and a number of alternatives are available depending on your qualitative preference. Matrices also don’t have to be square or even rectangular; polyomino-based dithering matrices have been explored as well[6].
Марк Успенский (Редактор отдела «Путешествия»)